Relationship between Vitamin D status and microbiome changes in Bulgarian patients with type 2 diabetes mellitus

The human microbiome plays a very important role in the normal functioning of both metabolic and immune systems. Changes gut microbiota (dysbiosis) possibly contribute to development autoimmune diseases. There is close association between Vitamin D metabolism. objective our study was characterize composition patients with type 2 diabetes mellitus (T2DM) comparison controls glucose tolerance, correlate status changes microbiome. Totally, 15 T2DM 16 were enrolled study. complex analysed by next generation sequencing (NGS) groups, additionally divided into subgroups according serum 25-hydroxyVitamin (25[OH]D) levels. We found significant decrease butyrate-producing bacteria Eubacterium spp. an increase lipopolysaccharide (LPS) - positive Enterobacter spp., Escherichia Pseudomonas compared controls. Control individuals 25[OH]D levels over 80 nmol/L characterized significantly decreased amount increased On other hand, < 80nmol/L diabetic related lower content higher LPS-positive bacteria. results showed influence on homeostasis relationship